Ideally I'd like humans to no longer have a collection of nerve endings in our elbows so there's no such thing as the funny bone so there's no need to go BLERGH when you accidentally hit it off something and instead you'd feel a normal pain as opposed to a completely bizarre pain.

Also, having some form of extra sense so we'd unconsciously manage to avert any chance of stubbing our toes/tripping up over anything.

Never having an impaired sense of balance despite whatever amount you may drink and similarly never reaching that point where you've drunk so much the room spins uncontrollably - instead feeling of drunkenness remains the same but we are left with the ability to walk and sit without our head moving about with or without us being conscious of it.

What say you?